Make Strawberries and Cream French Toast Casserole Recipe for a show-stopping, make-ahead brunch dish that bakes to golden perfection.
Spray a 9x13-inch baking pan thoroughly with nonstick spray so the casserole releases cleanly. Arrange half of the cubed bread evenly across the bottom of the prepared rectangular pan, building a flat, slightly rustic breadcrumb carpet with cubes snug but not crushed. Set the pan aside on the counter while you make the creamy layer.
In a medium bowl, beat the room-temperature cream cheese until it becomes silky and smooth. Add the powdered sugar, heavy cream, and vanilla extract, and continue beating until the mixture is glossy and spreadable, with tiny ribboned peaks — a thick yet spreadable cream that will hold its shape between bread layers and melt into pockets while baking.
Spread the cream cheese mixture in an even slab over the bed of bread cubes, using an offset spatula to create a smooth, consistent layer. Scatter two cups of sliced fresh strawberries across this cream cheese layer so bright red slices peek through the white cream, leaving the remaining cup of strawberries aside for garnish after baking.
Gently place the remaining half of the cubed bread over the strawberry-covered cream cheese, distributing cubes into a uniform top layer that covers the fruit but still reveals little strawberry tips and cream seams — the layered geometry should read clearly from above.
In a large mixing bowl whisk the eggs vigorously, then add milk, heavy cream, granulated sugar, pancake syrup, vanilla, and cinnamon, whisking until the custard is smooth and slightly glossy. The mixture should be homogenous, with no streaks, and have a custardy sheen that will soak into the bread and set into a soft, custard-like interior when baked.
Pour the whisked custard evenly over the top bread layer so the liquid pools into crevices and wets every cube; press lightly with a spatula to encourage absorption. Cover the rectangular pan tightly with plastic wrap and refrigerate overnight (or at least 8 hours) so the bread fully soaks the custard and the layers fuse into a uniform, saturated assembly.

Remove the fully soaked casserole from the refrigerator while your oven preheats to 350°F; the surface will look saturated but set, the cream cheese layer slightly visible between bread seams and strawberry cores still retaining color beneath the top layer of cubes.
Combine brown sugar, flour, and melted unsalted butter with a fork until the crumble is a sandy, slightly clumpy texture. Use your fingers to evenly sprinkle this crumble over the entire top of the soaked casserole so the topping nests into crevices and will crisp into golden shards during baking.
Cover the pan with aluminum foil and bake 20 minutes, then remove the foil and continue baking an additional 35 minutes (about 55 minutes total) until the topping is golden-brown and the middle no longer looks wet. If the center still jiggles or looks damp, bake a few more minutes until the custard is set but still moist.
After baking, let the casserole rest briefly, then sprinkle the reserved sliced strawberries across the warm, golden crumb top. Slice and serve rectangular portions warm on a matching rectangular plate, with an optional glass jar of pancake syrup on the side for drizzling.
